Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation

Nucleosomes form heterogeneous groups in vivo, named clutches. Clutches are smaller and less dense in mouse embryonic stem cells (ESCs) compared to neural progenitor cells (NPCs). Using coarse-grained modeling of the pluripotency Pou5f1 gene, we show that the genome-wide clutch differences between E...

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Detalles Bibliográficos
Autores principales: Gómez-García, Pablo Aurelio, Portillo-Ledesma, Stephanie, Neguembor, Maria Victoria, Pesaresi, Martina, Oweis, Walaa, Rohrlich, Talia, Wieser, Stefan, Meshorer, Eran, Schlick, Tamar, Cosma, Maria Pia, Lakadamyali, Melike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842188/
https://www.ncbi.nlm.nih.gov/pubmed/33440158
http://dx.doi.org/10.1016/j.celrep.2020.108614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842188/
https://www.ncbi.nlm.nih.gov/pubmed/33440158
http://dx.doi.org/10.1016/j.celrep.2020.108614

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