Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

To understand how neural-immune-associated genes and pathways contribute to neurodegenerative disease pathophysiology, we performed a systematic functional genomic analysis in purified microglia and bulk tissue from mouse and human AD, FTD, and PSP. We uncover a complex temporal trajectory of microg...

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Detalles Bibliográficos
Autores principales: Rexach, Jessica E., Polioudakis, Damon, Yin, Anna, Swarup, Vivek, Chang, Timothy S., Nguyen, Tam, Sarkar, Arjun, Chen, Lawrence, Huang, Jerry, Lin, Li-Chun, Seeley, William, Trojanowski, John Q., Malhotra, Dheeraj, Geschwind, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842189/
https://www.ncbi.nlm.nih.gov/pubmed/33207193
http://dx.doi.org/10.1016/j.celrep.2020.108398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842189/
https://www.ncbi.nlm.nih.gov/pubmed/33207193
http://dx.doi.org/10.1016/j.celrep.2020.108398

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