Correction of arginine metabolism with sepiapterin—the precursor of nitric oxide synthase cofactor BH(4)—induces immunostimulatory-shift of breast cancer

Immunotherapy is a first-line treatment for many tumor types. However, most breast tumors are immunosuppressive and only modestly respond to immunotherapy. We hypothesized that correcting arginine metabolism might improve the immunogenicity of breast tumors. We tested whether supplementing sepiapter...

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Detalles Bibliográficos
Autores principales: Zheng, Xunzhen, Fernando, Veani, Sharma, Vandana, Walia, Yashna, Letson, Joshua, Furuta, Saori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842273/
https://www.ncbi.nlm.nih.gov/pubmed/32112882
http://dx.doi.org/10.1016/j.bcp.2020.113887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842273/
https://www.ncbi.nlm.nih.gov/pubmed/32112882
http://dx.doi.org/10.1016/j.bcp.2020.113887

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