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Correction of arginine metabolism with sepiapterin—the precursor of nitric oxide synthase cofactor BH(4)—induces immunostimulatory-shift of breast cancer
Immunotherapy is a first-line treatment for many tumor types. However, most breast tumors are immunosuppressive and only modestly respond to immunotherapy. We hypothesized that correcting arginine metabolism might improve the immunogenicity of breast tumors. We tested whether supplementing sepiapter...
Autores principales: | Zheng, Xunzhen, Fernando, Veani, Sharma, Vandana, Walia, Yashna, Letson, Joshua, Furuta, Saori |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842273/ https://www.ncbi.nlm.nih.gov/pubmed/32112882 http://dx.doi.org/10.1016/j.bcp.2020.113887 |
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