Targeting evolution of antibiotic resistance by SOS response inhibition

Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-depended mutagenesis and horizontal gene transfer pathways. Compounds able to inhibit SOS response are extremely important to develop new combinatorial strategies aimed to block mutagenesis. The regulators of homol...

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Detalles Bibliográficos
Autores principales: Yakimov, Alexander, Bakhlanova, Irina, Baitin, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843400/
https://www.ncbi.nlm.nih.gov/pubmed/33552448
http://dx.doi.org/10.1016/j.csbj.2021.01.003
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author Yakimov, Alexander
Bakhlanova, Irina
Baitin, Dmitry
author_facet Yakimov, Alexander
Bakhlanova, Irina
Baitin, Dmitry
author_sort Yakimov, Alexander
collection PubMed
description Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-depended mutagenesis and horizontal gene transfer pathways. Compounds able to inhibit SOS response are extremely important to develop new combinatorial strategies aimed to block mutagenesis. The regulators of homologous recombination involved in the processes of DNA repair should be considered as potential targets for blocking. This review highlights the current knowledge of the protein targets for the evolution of antibiotic resistance and the inhibitory effects of some new compounds on this pathway.
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spelling pubmed-78434002021-02-04 Targeting evolution of antibiotic resistance by SOS response inhibition Yakimov, Alexander Bakhlanova, Irina Baitin, Dmitry Comput Struct Biotechnol J Review Article Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-depended mutagenesis and horizontal gene transfer pathways. Compounds able to inhibit SOS response are extremely important to develop new combinatorial strategies aimed to block mutagenesis. The regulators of homologous recombination involved in the processes of DNA repair should be considered as potential targets for blocking. This review highlights the current knowledge of the protein targets for the evolution of antibiotic resistance and the inhibitory effects of some new compounds on this pathway. Research Network of Computational and Structural Biotechnology 2021-01-11 /pmc/articles/PMC7843400/ /pubmed/33552448 http://dx.doi.org/10.1016/j.csbj.2021.01.003 Text en © 2021 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Yakimov, Alexander
Bakhlanova, Irina
Baitin, Dmitry
Targeting evolution of antibiotic resistance by SOS response inhibition
title Targeting evolution of antibiotic resistance by SOS response inhibition
title_full Targeting evolution of antibiotic resistance by SOS response inhibition
title_fullStr Targeting evolution of antibiotic resistance by SOS response inhibition
title_full_unstemmed Targeting evolution of antibiotic resistance by SOS response inhibition
title_short Targeting evolution of antibiotic resistance by SOS response inhibition
title_sort targeting evolution of antibiotic resistance by sos response inhibition
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843400/
https://www.ncbi.nlm.nih.gov/pubmed/33552448
http://dx.doi.org/10.1016/j.csbj.2021.01.003
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