Role of TLR4 in Persistent Leptospira interrogans Infection: A Comparative In Vivo Study in Mice

Toll-Like Receptor (TLR) 4, the LPS receptor, plays a central role in the control of leptospirosis and absence of TLR4 results in lethal infection in mice. Because human TLR4 does not sense the atypical leptospiral-LPS, we hypothesized that TLR4/MD-2 humanized transgenic mice (huTLR4) may be more su...

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Detalles Bibliográficos
Autores principales: Nair, Nisha, Guedes, Mariana S., Hajjar, Adeline M., Werts, Catherine, Gomes-Solecki, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843520/
https://www.ncbi.nlm.nih.gov/pubmed/33519799
http://dx.doi.org/10.3389/fimmu.2020.572999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843520/
https://www.ncbi.nlm.nih.gov/pubmed/33519799
http://dx.doi.org/10.3389/fimmu.2020.572999

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