The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis

Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed lineage kinase domain-like (MLKL). Previous studies suggested a role for the necroptotic machinery in platelets, where loss of MLKL or its upstream regulator, RIPK3 kinase, impacted thrombosis and haemostas...

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Detalles Bibliográficos
Autores principales: Moujalled, Diane, Gangatirkar, Pradnya, Kauppi, Maria, Corbin, Jason, Lebois, Marion, Murphy, James M., Lalaoui, Najoua, Hildebrand, Joanne M., Silke, John, Alexander, Warren S., Josefsson, Emma C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843594/
https://www.ncbi.nlm.nih.gov/pubmed/33510145
http://dx.doi.org/10.1038/s41419-021-03418-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843594/
https://www.ncbi.nlm.nih.gov/pubmed/33510145
http://dx.doi.org/10.1038/s41419-021-03418-z

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