Transforming early pharmaceutical assessment of genotoxicity: applying statistical learning to a high throughput, multi end point in vitro micronucleus assay

To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuclei and multiple additional cellular markers associated wit...

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Detalles Bibliográficos
Autores principales: Wilson, Amy, Grabowski, Piotr, Elloway, Joanne, Ling, Stephanie, Stott, Jonathan, Doherty, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844000/
https://www.ncbi.nlm.nih.gov/pubmed/33510380
http://dx.doi.org/10.1038/s41598-021-82115-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844000/
https://www.ncbi.nlm.nih.gov/pubmed/33510380
http://dx.doi.org/10.1038/s41598-021-82115-5

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