Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABA(A) Receptors

Pyrazoloquinolinones (PQs) are a versatile class of GABA(A) receptor ligands. It has been demonstrated that high functional selectivity for certain receptor subtypes can be obtained by specific substitution patterns, but so far, no clear SAR rules emerge from the studies. As is the case for many GAB...

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Detalles Bibliográficos
Autores principales: Fabjan, Jure, Koniuszewski, Filip, Schaar, Benjamin, Ernst, Margot
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844064/
https://www.ncbi.nlm.nih.gov/pubmed/33519364
http://dx.doi.org/10.3389/fnins.2020.611953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844064/
https://www.ncbi.nlm.nih.gov/pubmed/33519364
http://dx.doi.org/10.3389/fnins.2020.611953

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