Cargando…
Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway
BACKGROUND: Acute myocardial infarction (AMI) is one of the leading causes of morbidity and death worldwide. Studies have indicated that microRNAs in mesenchymal stem cell (MSC)-derived exosomes are crucial for treating various diseases. METHODS: Human umbilical cord MSC (hucMSC)-derived exosomes (h...
Autores principales: | Liang, Chenyu, Liu, Yang, Xu, Huifeng, Huang, Junling, Shen, Yi, Chen, Faxiu, Luo, Ming |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844314/ https://www.ncbi.nlm.nih.gov/pubmed/33520966 http://dx.doi.org/10.3389/fbioe.2020.615850 |
Ejemplares similares
-
Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes
por: Qiu, Zhen, et al.
Publicado: (2019) -
MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy
por: Li, X, et al.
Publicado: (2014) -
Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair
por: Zhang, Ning, et al.
Publicado: (2020) -
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Oxygen-Glucose Deprivation/Reperfusion-Induced Microglial Pyroptosis by Promoting FOXO3a-Dependent Mitophagy
por: Hu, Zhenzhen, et al.
Publicado: (2021) -
Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism
por: Cho, Siyoung, et al.
Publicado: (2014)