iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities

Cardiac complications such as electrical abnormalities including conduction delays and arrhythmias are the main cause of death in individuals with Myotonic Dystrophy type 1 (DM1). We developed a disease model using iPSC-derived cardiomyocytes (iPSC-CMs) from a healthy individual and two DM1 patients...

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Detalles Bibliográficos
Autores principales: Poulin, Hugo, Mercier, Aurélie, Djemai, Mohammed, Pouliot, Valérie, Deschenes, Isabelle, Boutjdir, Mohamed, Puymirat, Jack, Chahine, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844414/
https://www.ncbi.nlm.nih.gov/pubmed/33510259
http://dx.doi.org/10.1038/s41598-021-82007-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844414/
https://www.ncbi.nlm.nih.gov/pubmed/33510259
http://dx.doi.org/10.1038/s41598-021-82007-8

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