Pathogenic mutations in the kinesin-3 motor KIF1A diminish force generation and movement through allosteric mechanisms

The kinesin-3 motor KIF1A functions in neurons, where its fast and superprocessive motility facilitates long-distance transport, but little is known about its force-generating properties. Using optical tweezers, we demonstrate that KIF1A stalls at an opposing load of ~3 pN but more frequently detach...

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Detalles Bibliográficos
Autores principales: Budaitis, Breane G., Jariwala, Shashank, Rao, Lu, Yue, Yang, Sept, David, Verhey, Kristen J., Gennerich, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844421/
https://www.ncbi.nlm.nih.gov/pubmed/33496723
http://dx.doi.org/10.1083/jcb.202004227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844421/
https://www.ncbi.nlm.nih.gov/pubmed/33496723
http://dx.doi.org/10.1083/jcb.202004227

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