Cargando…

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Most antimicrobials currently in the clinical pipeline are modifications of existing classes of antibiotics and are considered short-term solutions due to the emergence of resistance. Pseudomonas aeruginosa represents a major challenge for new antimicrobial drug discovery due to its versatile lifest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moustafa, Dina A., Wu, Ashley W., Zamora, Danniel, Daly, Seth M., Sturge, Carolyn R., Pybus, Christine, Geller, Bruce L., Goldberg, Joanna B., Greenberg, David E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7844538/ https://www.ncbi.nlm.nih.gov/pubmed/33436433 http://dx.doi.org/10.1128/mBio.02411-20

Ejemplares similares

MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli
por: Daly, Seth M., et al.
Publicado: (2017)

In Vitro Validation of Phosphorodiamidate Morpholino Oligomers
por: Aung-Htut, May T., et al.
Publicado: (2019)

292. Phosphorodiamidate Morpholino Oligomers Targeting acpP Reduce the Biofilm Burden in Burkholderia cepacia Complex
por: Mendez, Antonio R, et al.
Publicado: (2023)

Antisense Phosphorodiamidate Morpholino Oligomers as Novel Antiviral Compounds
por: Nan, Yuchen, et al.
Publicado: (2018)

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers
por: Li, Chengxi, et al.
Publicado: (2021)

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice
por: Ran, Ning, et al.
Publicado: (2020)

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers for In Situ Live-Cell Molecular Imaging of Dengue Virus Replication
por: Victorio, Carla Bianca Luena, et al.
Publicado: (2020)

Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers
por: Warfield, Kelly L, et al.
Publicado: (2006)

Development of Novel Bioanalytical Methods to Determine the Effective Concentrations of Phosphorodiamidate Morpholino Oligomers in Tissues and Cells
por: Schnell, Frederick J., et al.
Publicado: (2013)

Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice
por: Mukashyaka, Marie Claire, et al.
Publicado: (2021)

A cell-penetrating peptide enhances delivery and efficacy of phosphorodiamidate morpholino oligomers in mdx mice
por: Gan, Li, et al.
Publicado: (2022)

Antiviral Phosphorodiamidate Morpholino Oligomers are Protective against Chikungunya Virus Infection on Cell-based and Murine Models
por: Lam, Shirley, et al.
Publicado: (2015)

Combined Treatment with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer-PPMO and AAV-U7 Rescues the Severe DMD Phenotype in Mice
por: Forand, Anne, et al.
Publicado: (2020)

Convergent synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) by the H-phosphonate approach
por: Tsurusaki, Taiki, et al.
Publicado: (2023)

A Single Phosphorodiamidate Morpholino Oligomer Targeting VP24 Protects Rhesus Monkeys against Lethal Ebola Virus Infection
por: Warren, Travis K., et al.
Publicado: (2015)

Therapeutic phosphorodiamidate morpholino oligonucleotides: Physical properties, solution structures, and folding thermodynamics
por: Maksudov, Farkhad, et al.
Publicado: (2023)

Shorter Phosphorodiamidate Morpholino Splice-Switching Oligonucleotides May Increase Exon-Skipping Efficacy in DMD
por: Akpulat, Ugur, et al.
Publicado: (2018)

Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity
por: Schissel, Carly K., et al.
Publicado: (2022)

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study
por: Cirak, Sebahattin, et al.
Publicado: (2011)

2065. Efficacy of D-peptide-conjugated Antisense Compounds Against Pseudomonas aeruginosa
por: Koch, Rachelle E, et al.
Publicado: (2023)

Antiviral and Neuroprotective Role of Octaguanidinium Dendrimer-Conjugated Morpholino Oligomers in Japanese Encephalitis
por: Nazmi, Arshed, et al.
Publicado: (2010)

Inhibition of enterovirus 71 infection by antisense octaguanidinium dendrimer-conjugated morpholino oligomers
por: Tan, Chee Wah, et al.
Publicado: (2014)

Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication
por: Patel, Deendayal, et al.
Publicado: (2008)

Cefiderocol Retains Antibiofilm Activity in Multidrug-Resistant Gram-Negative Pathogens
por: Pybus, Christine A., et al.
Publicado: (2021)

Advanced morpholino oligomers: A novel approach to antiviral therapy
por: Warren, Travis K., et al.
Publicado: (2012)

Coordinate control of cell cycle regulatory genes in zebrafish development tested by cyclin D1 knockdown with morpholino phosphorodiamidates and hydroxyprolyl-phosphono peptide nucleic acids
por: Duffy, Kevin T., et al.
Publicado: (2005)

Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers
por: Paessler, Slobodan, et al.
Publicado: (2008)

Inhibition of KSHV-associated lymphoma engraftment in SCID mouse by morpholino oligomers
por: Nan, Yuchen, et al.
Publicado: (2010)

Manipulation of gene expression in zebrafish using caged circular morpholino oligomers
por: Wang, Yuan, et al.
Publicado: (2012)

Inhibition of norovirus replication by morpholino oligomers targeting the 5′-end of the genome
por: Bok, Karin, et al.
Publicado: (2008)

Inhibition and Escape of SARS-CoV Treated with Antisense Morpholino Oligomers
por: Neuman, Benjamin W., et al.
Publicado: (2006)

Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein
por: Li, Dunhui, et al.
Publicado: (2020)

Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers
por: Zhang, Yan-Jin, et al.
Publicado: (2006)

Curing of HeLa cells persistently infected with equine arteritis virus by a peptide-conjugated morpholino oligomer
por: Zhang, Jianqiang, et al.
Publicado: (2010)

Hexose Potentiates Peptide-Conjugated Morpholino Oligomer Efficacy in Cardiac Muscles of Dystrophic Mice in an Age-Dependent Manner
por: Han, Gang, et al.
Publicado: (2019)

A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy
por: Viola, Helena M., et al.
Publicado: (2018)

Enhanced inhibition of porcine reproductive and respiratory syndrome virus replication by combination of morpholino oligomers
por: Han, Xue, et al.
Publicado: (2009)

Practical Synthesis of Quinoline-Protected Morpholino Oligomers for Light-Triggered Regulation of Gene Function
por: Deodato, Davide, et al.
Publicado: (2020)

Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice
por: Han, Gang, et al.
Publicado: (2018)

Long-Term Morpholino Oligomers in Hexose Elicit Long-Lasting Therapeutic Improvements in mdx Mice
por: Han, Gang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d3gqcji4shr2dljlppvum5fun4