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Residue-Selective Protein C-Formylation via Sequential Difluoroalkylation-Hydrolysis

[Image: see text] The carbonyl group is now a widely useful, nonproteinogenic functional group in chemical biology, yet methods for its generation in proteins have relied upon either cotranslational incorporation of unnatural amino acids bearing carbonyls or oxidative conversion (chemical or enzymat...

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Detalles Bibliográficos
Autores principales: Imiołek, Mateusz, Isenegger, Patrick G., Ng, Wai-Lung, Khan, Aziz, Gouverneur, Véronique, Davis, Benjamin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845020/
https://www.ncbi.nlm.nih.gov/pubmed/33532577
http://dx.doi.org/10.1021/acscentsci.0c01193