High heterogeneity undermines generalization of differential expression results in RNA-Seq analysis

BACKGROUND: RNA sequencing (RNA-Seq) has been widely applied in oncology for monitoring transcriptome changes. However, the emerging problem that high variation of gene expression levels caused by tumor heterogeneity may affect the reproducibility of differential expression (DE) results has rarely b...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Weitong, Xue, Huaru, Wei, Lei, Jin, Jinghua, Tian, Xuewen, Wang, Qinglu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845028/
https://www.ncbi.nlm.nih.gov/pubmed/33509298
http://dx.doi.org/10.1186/s40246-021-00308-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845028/
https://www.ncbi.nlm.nih.gov/pubmed/33509298
http://dx.doi.org/10.1186/s40246-021-00308-5

Ejemplares similares