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High heterogeneity undermines generalization of differential expression results in RNA-Seq analysis
BACKGROUND: RNA sequencing (RNA-Seq) has been widely applied in oncology for monitoring transcriptome changes. However, the emerging problem that high variation of gene expression levels caused by tumor heterogeneity may affect the reproducibility of differential expression (DE) results has rarely b...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845028/ https://www.ncbi.nlm.nih.gov/pubmed/33509298 http://dx.doi.org/10.1186/s40246-021-00308-5 |