Changes in the brain transcriptome after DNA Aβ42 trimer immunization in a 3xTg-AD mouse model

Alzheimer’s disease (AD) has been associated with accumulation of amyloid beta (Aβ) peptides in brain, and immunotherapy targeting Aβ provides potential for AD prevention. We have used a DNA Aβ42 trimer construct for immunization of 3xTg-AD mice and found previously significant reduction of amyloid...

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Detalles Bibliográficos
Autores principales: Lambracht-Washington, Doris, Fu, Min, Hynan, Linda S., Rosenberg, Roger N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845550/
https://www.ncbi.nlm.nih.gov/pubmed/33316368
http://dx.doi.org/10.1016/j.nbd.2020.105221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845550/
https://www.ncbi.nlm.nih.gov/pubmed/33316368
http://dx.doi.org/10.1016/j.nbd.2020.105221

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