Cargando…

Changes in the brain transcriptome after DNA Aβ42 trimer immunization in a 3xTg-AD mouse model

Alzheimer’s disease (AD) has been associated with accumulation of amyloid beta (Aβ) peptides in brain, and immunotherapy targeting Aβ provides potential for AD prevention. We have used a DNA Aβ42 trimer construct for immunization of 3xTg-AD mice and found previously significant reduction of amyloid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lambracht-Washington, Doris, Fu, Min, Hynan, Linda S., Rosenberg, Roger N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845550/ https://www.ncbi.nlm.nih.gov/pubmed/33316368 http://dx.doi.org/10.1016/j.nbd.2020.105221

Ejemplares similares

Glial cell transcriptome analyses in 3xTg-AD mice: Effects of aging, disease progression, and anti-Aβ immunotherapy
por: Lambracht-Washington, Doris, et al.
Publicado: (2023)

Active full-length DNA Aβ(42) immunization in 3xTg-AD mice reduces not only amyloid deposition but also tau pathology
por: Rosenberg, Roger N., et al.
Publicado: (2018)

Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer
por: Lambracht-Washington, Doris, et al.
Publicado: (2017)

Evaluation of a DNA Aβ(42) Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ(42) Trimer
por: Lambracht-Washington, Doris, et al.
Publicado: (2017)

Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Stimmell, Alina C., et al.
Publicado: (2019)

Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Javonillo, Dominic I., et al.
Publicado: (2022)

Abnormal whisker movements in the 3xTg‐AD mouse model of Alzheimer's disease
por: Simanaviciute, Ugne, et al.
Publicado: (2022)

Olfactory dysfunction in the 3xTg-AD model of Alzheimer’s disease
por: Mitrano, Darlene A., et al.
Publicado: (2021)

Progressive Vascular Abnormalities in the Aging 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Jullienne, Amandine, et al.
Publicado: (2022)

Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer’s disease
por: Gloria, Yesica, et al.
Publicado: (2021)

Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Kane, Alice E., et al.
Publicado: (2018)

Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer’s disease
por: Alkhouli, Mustafa F., et al.
Publicado: (2019)

Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical Research
por: Dennison, Jessica L., et al.
Publicado: (2021)

Low-Dose Chidamide Treatment Displays Sex-Specific Differences in the 3xTg-AD Mouse
por: Dennison, Jessica, et al.
Publicado: (2023)

IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology
por: St-Amour, Isabelle, et al.
Publicado: (2014)

Whole Blood Transcriptome Characterization of 3xTg-AD Mouse and Its Modulation by Transcranial Direct Current Stimulation (tDCS)
por: Magri, Chiara, et al.
Publicado: (2021)

Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice
por: Giménez-Llort, Lydia, et al.
Publicado: (2010)

Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Ruzicka, Jiri, et al.
Publicado: (2016)

Microglial Activation in the Retina of a Triple-Transgenic Alzheimer’s Disease Mouse Model (3xTg-AD)
por: Salobrar-García, Elena, et al.
Publicado: (2020)

Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease
por: Robison, Lisa S., et al.
Publicado: (2023)

Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer’s Disease is Affected by Aβ-ImmunoTherapy and Cognitive Stimulation
por: Roda, Alejandro R., et al.
Publicado: (2020)

Reducing AD-Like Pathology in 3xTg-AD Mouse Model by DNA Epitope Vaccine — A Novel Immunotherapeutic Strategy
por: Movsesyan, Nina, et al.
Publicado: (2008)

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice
por: Chen, Yanxing, et al.
Publicado: (2014)

Temporal and regional progression of Alzheimer’s disease‐like pathology in 3xTg‐AD mice
por: Belfiore, Ramona, et al.
Publicado: (2018)

Neuroprotective Effects of Probiotic-Supplemented Diet on Cognitive Behavior of 3xTg-AD Mice
por: Tan, Chenxi, et al.
Publicado: (2022)

Age-dependent inverse correlations in CSF and plasma amyloid-β(1–42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice
por: Cho, Soo Min, et al.
Publicado: (2016)

Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer’s disease
por: Ye, Minsook, et al.
Publicado: (2016)

Supragranular Pyramidal Cells Exhibit Early Metabolic Alterations in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Piquet, Juliette, et al.
Publicado: (2018)

Inflammation, neurodegeneration and protein aggregation in the retina as ocular biomarkers for Alzheimer’s disease in the 3xTg-AD mouse model
por: Grimaldi, Alfonso, et al.
Publicado: (2018)

Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model
por: Janczura, Karolina J., et al.
Publicado: (2018)

Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Broderick, Tom L., et al.
Publicado: (2020)

β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice
por: Piedrahita, Diego, et al.
Publicado: (2016)

Maternal High Fat Diet Anticipates the AD-like Phenotype in 3xTg-AD Mice by Epigenetic Dysregulation of Aβ Metabolism
por: Natale, Francesca, et al.
Publicado: (2023)

Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer’s disease
por: Robison, Lisa S., et al.
Publicado: (2020)

IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer’s Disease
por: Escrig, Anna, et al.
Publicado: (2020)

Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer’s Disease Patient Astrocytes Impair Neuroglial and Vascular Components
por: González-Molina, Luis Alfonso, et al.
Publicado: (2021)

Treatment of Alzheimer's Disease with Anti-Homocysteic Acid Antibody in 3xTg-AD Male Mice
por: Hasegawa, Tohru, et al.
Publicado: (2010)

DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice
por: Arsenault, Dany, et al.
Publicado: (2011)

Early and sustained altered expression of aging-related genes in young 3xTg-AD mice
por: Gatta, V, et al.
Publicado: (2014)

Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice
por: Van der Jeugd, Ann, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t59jt7hcce60o9odp02gqsl6eo