The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress

The DNA demethylating agent 5-aza-2′-deoxycytidine (DAC, decitabine) has anti-cancer therapeutic potential, but its clinical efficacy is hindered by DNA damage-related side effects and its use in solid tumours is debated. Here we describe how paracetamol augments the effects of DAC on cancer cell pr...

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Detalles Bibliográficos
Autores principales: Gleneadie, Hannah J., Baker, Amy H., Batis, Nikolaos, Bryant, Jennifer, Jiang, Yao, Clokie, Samuel J.H., Mehanna, Hisham, Garcia, Paloma, Gendoo, Deena M.A., Roberts, Sally, Burley, Megan, Molinolo, Alfredo A., Gutkind, J. Silvio, Scheven, Ben A., Cooper, Paul R., Parish, Joanna L., Khanim, Farhat L., Wiench, Malgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ireland 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845757/
https://www.ncbi.nlm.nih.gov/pubmed/33359448
http://dx.doi.org/10.1016/j.canlet.2020.12.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845757/
https://www.ncbi.nlm.nih.gov/pubmed/33359448
http://dx.doi.org/10.1016/j.canlet.2020.12.029

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