Loss of the K(+) channel K(v)2.1 greatly reduces outward dark current and causes ionic dysregulation and degeneration in rod photoreceptors

Vertebrate retinal photoreceptors signal light by suppressing a circulating “dark current” that maintains their relative depolarization in the dark. This dark current is composed of an inward current through CNG channels and NCKX transporters in the outer segment that is balanced by outward current...

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Detalles Bibliográficos
Autores principales: Fortenbach, Christopher, Peinado Allina, Gabriel, Shores, Camilla M., Karlen, Sarah J., Miller, Eric B., Bishop, Hannah, Trimmer, James S., Burns, Marie E., Pugh, Edward N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845921/
https://www.ncbi.nlm.nih.gov/pubmed/33502442
http://dx.doi.org/10.1085/jgp.202012687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845921/
https://www.ncbi.nlm.nih.gov/pubmed/33502442
http://dx.doi.org/10.1085/jgp.202012687

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