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Loss of the K(+) channel K(v)2.1 greatly reduces outward dark current and causes ionic dysregulation and degeneration in rod photoreceptors
Vertebrate retinal photoreceptors signal light by suppressing a circulating “dark current” that maintains their relative depolarization in the dark. This dark current is composed of an inward current through CNG channels and NCKX transporters in the outer segment that is balanced by outward current...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845921/ https://www.ncbi.nlm.nih.gov/pubmed/33502442 http://dx.doi.org/10.1085/jgp.202012687 |