Mechanism of C-type inactivation in the hERG potassium channel

The fast C-type inactivation displayed by the voltage-activated potassium channel hERG plays a critical role in the repolarization of cardiac cells, and malfunction caused by nonspecific binding of drugs or naturally occurring missense mutations affecting inactivation can lead to pathologies. Becaus...

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Detalles Bibliográficos
Autores principales: Li, Jing, Shen, Rong, Reddy, Bharat, Perozo, Eduardo, Roux, Benoît
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846155/
https://www.ncbi.nlm.nih.gov/pubmed/33514547
http://dx.doi.org/10.1126/sciadv.abd6203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846155/
https://www.ncbi.nlm.nih.gov/pubmed/33514547
http://dx.doi.org/10.1126/sciadv.abd6203

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