Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development

Deficiency in the DNA end-processing enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1), causes progressive neurodegeneration in humans. Here, we generated a tdp1 knockout zebrafish and confirmed the lack of TDP1 activity. In adulthood, homozygotes exhibit hypersensitivity to topoisomerase 1 (Top1) pois...

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Detalles Bibliográficos
Autores principales: Zaksauskaite, Ringaile, Thomas, Ruth C, van Eeden, Freek, El-Khamisy, Sherif F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846158/
https://www.ncbi.nlm.nih.gov/pubmed/33514542
http://dx.doi.org/10.1126/sciadv.abc4165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846158/
https://www.ncbi.nlm.nih.gov/pubmed/33514542
http://dx.doi.org/10.1126/sciadv.abc4165

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