A promiscuous ancestral enzyme´s structure unveils protein variable regions of the highly diverse metallo-β-lactamase family

The metallo-β-lactamase fold is an ancient protein structure present in numerous enzyme families responsible for diverse biological processes. The crystal structure of the hyperthermostable crenarchaeal enzyme Igni18 from Ignicoccus hospitalis was solved at 2.3 Å and could resemble a possible first...

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Detalles Bibliográficos
Autores principales: Perez-Garcia, Pablo, Kobus, Stefanie, Gertzen, Christoph G. W., Hoeppner, Astrid, Holzscheck, Nicholas, Strunk, Christoph Heinrich, Huber, Harald, Jaeger, Karl-Erich, Gohlke, Holger, Kovacic, Filip, Smits, Sander H. J., Streit, Wolfgang R., Chow, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846560/
https://www.ncbi.nlm.nih.gov/pubmed/33514861
http://dx.doi.org/10.1038/s42003-021-01671-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846560/
https://www.ncbi.nlm.nih.gov/pubmed/33514861
http://dx.doi.org/10.1038/s42003-021-01671-8

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