Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics

Infiltrative growth is a major cause of high lethality of malignant brain tumors such as glioblastoma (GBM). We show here that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness. Deletion of Plexin-B2 in GBM stem cells limited tumor spread and shifted invasion paths from axon fibe...

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Detalles Bibliográficos
Autores principales: Huang, Yong, Tejero, Rut, Lee, Vivian K., Brusco, Concetta, Hannah, Theodore, Bertucci, Taylor B., Junqueira Alves, Chrystian, Katsyv, Igor, Kluge, Michael, Foty, Ramsey, Zhang, Bin, Friedel, Caroline C., Dai, Guohao, Zou, Hongyan, Friedel, Roland H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846610/
https://www.ncbi.nlm.nih.gov/pubmed/33514835
http://dx.doi.org/10.1038/s42003-021-01667-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846610/
https://www.ncbi.nlm.nih.gov/pubmed/33514835
http://dx.doi.org/10.1038/s42003-021-01667-4

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