NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins

The Neisseria meningitidis protein FrpC contains a self-processing module (SPM) undergoing autoproteolysis via an aspartic anhydride. Herein, we establish NeissLock, using a binding protein genetically fused to SPM. Upon calcium triggering of SPM, the anhydride at the C-terminus of the binding prote...

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Detalles Bibliográficos
Autores principales: Scheu, Arne H. A., Lim, Sheryl Y. T., Metzner, Felix J., Mohammed, Shabaz, Howarth, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846742/
https://www.ncbi.nlm.nih.gov/pubmed/33514717
http://dx.doi.org/10.1038/s41467-021-20963-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846742/
https://www.ncbi.nlm.nih.gov/pubmed/33514717
http://dx.doi.org/10.1038/s41467-021-20963-5

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