LC–MS based case-by-case analysis of the impact of acidic and basic charge variants of bevacizumab on stability and biological activity

The present study investigates the impact of charge variants on bevacizumab's structure, stability, and biological activity. Five basic and one acidic charge variants were separated using semi-preparative cation exchange chromatography using linear pH gradient elution with purity > 85%. Base...

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Detalles Bibliográficos
Autores principales: Singh, Sumit Kumar, Kumar, Deepak, Malani, Himanshu, Rathore, Anurag S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846745/
https://www.ncbi.nlm.nih.gov/pubmed/33514790
http://dx.doi.org/10.1038/s41598-020-79541-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846745/
https://www.ncbi.nlm.nih.gov/pubmed/33514790
http://dx.doi.org/10.1038/s41598-020-79541-2

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