Structural basis for a complex I mutation that blocks pathological ROS production

Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia–reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point mutation encoding the P25L substitution in the ND6 subunit of complex I. The cryo-E...

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Detalles Bibliográficos
Autores principales: Yin, Zhan, Burger, Nils, Kula-Alwar, Duvaraka, Aksentijević, Dunja, Bridges, Hannah R., Prag, Hiran A., Grba, Daniel N., Viscomi, Carlo, James, Andrew M., Mottahedin, Amin, Krieg, Thomas, Murphy, Michael P., Hirst, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846746/
https://www.ncbi.nlm.nih.gov/pubmed/33514727
http://dx.doi.org/10.1038/s41467-021-20942-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846746/
https://www.ncbi.nlm.nih.gov/pubmed/33514727
http://dx.doi.org/10.1038/s41467-021-20942-w

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