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Structural basis for a complex I mutation that blocks pathological ROS production
Mitochondrial complex I is central to the pathological reactive oxygen species (ROS) production that underlies cardiac ischemia–reperfusion (IR) injury. ND6-P25L mice are homoplasmic for a disease-causing mtDNA point mutation encoding the P25L substitution in the ND6 subunit of complex I. The cryo-E...
Autores principales: | Yin, Zhan, Burger, Nils, Kula-Alwar, Duvaraka, Aksentijević, Dunja, Bridges, Hannah R., Prag, Hiran A., Grba, Daniel N., Viscomi, Carlo, James, Andrew M., Mottahedin, Amin, Krieg, Thomas, Murphy, Michael P., Hirst, Judy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846746/ https://www.ncbi.nlm.nih.gov/pubmed/33514727 http://dx.doi.org/10.1038/s41467-021-20942-w |
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