PDX1(LOW) MAFA(LOW) β-cells contribute to islet function and insulin release

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such diversity contributes to insulin release remains poorly understood. Here we show that subtle differences in β-cell maturity, defined using PDX1 and MAFA expression, contribute to islet operation. Functional mappi...

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Detalles Bibliográficos
Autores principales: Nasteska, Daniela, Fine, Nicholas H. F., Ashford, Fiona B., Cuozzo, Federica, Viloria, Katrina, Smith, Gabrielle, Dahir, Aisha, Dawson, Peter W. J., Lai, Yu-Chiang, Bastidas-Ponce, Aimée, Bakhti, Mostafa, Rutter, Guy A., Fiancette, Remi, Nano, Rita, Piemonti, Lorenzo, Lickert, Heiko, Zhou, Qiao, Akerman, Ildem, Hodson, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846747/
https://www.ncbi.nlm.nih.gov/pubmed/33514698
http://dx.doi.org/10.1038/s41467-020-20632-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846747/
https://www.ncbi.nlm.nih.gov/pubmed/33514698
http://dx.doi.org/10.1038/s41467-020-20632-z

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