De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

The aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours and may silence the expression of tumour suppressors such as MLH1. Current models propose that these CpG islands are targeted by de novo DNA methyltransferases in a sequence-specific manner, but this has...

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Detalles Bibliográficos
Autores principales: Masalmeh, Roza H. Ali, Taglini, Francesca, Rubio-Ramon, Cristina, Musialik, Kamila I., Higham, Jonathan, Davidson-Smith, Hazel, Kafetzopoulos, Ioannis, Pawlicka, Kamila P., Finan, Hannah M., Clark, Richard, Wills, Jimi, Finch, Andrew J., Murphy, Lee, Sproul, Duncan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846778/
https://www.ncbi.nlm.nih.gov/pubmed/33514701
http://dx.doi.org/10.1038/s41467-020-20716-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846778/
https://www.ncbi.nlm.nih.gov/pubmed/33514701
http://dx.doi.org/10.1038/s41467-020-20716-w

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