DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously

We report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1,...

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Detalles Bibliográficos
Autores principales: Beckmann, Roland, Jensen, Kristian, Fenn, Sebastian, Speck, Janina, Krause, Katrin, Meier, Anastasia, Röth, Melanie, Fauser, Sascha, Kimbung, Raymond, Logan, Derek T., Steegmaier, Martin, Kettenberger, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846786/
https://www.ncbi.nlm.nih.gov/pubmed/33514724
http://dx.doi.org/10.1038/s41467-021-20949-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846786/
https://www.ncbi.nlm.nih.gov/pubmed/33514724
http://dx.doi.org/10.1038/s41467-021-20949-3

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