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Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure

Heart failure (HF) occurs frequently among older individuals, and dysfunction of cardiac mitochondria is often observed. We here show the cardiac-specific downregulation of a certain mitochondrial component during the chronological aging of mice, which is detrimental to the heart. MitoNEET is a mito...

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Detalles Bibliográficos
Autores principales: Furihata, Takaaki, Takada, Shingo, Kakutani, Naoya, Maekawa, Satoshi, Tsuda, Masaya, Matsumoto, Junichi, Mizushima, Wataru, Fukushima, Arata, Yokota, Takashi, Enzan, Nobuyuki, Matsushima, Shouji, Handa, Haruka, Fumoto, Yoshizuki, Nio-Kobayashi, Junko, Iwanaga, Toshihiko, Tanaka, Shinya, Tsutsui, Hiroyuki, Sabe, Hisataka, Kinugawa, Shintaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846856/
https://www.ncbi.nlm.nih.gov/pubmed/33514783
http://dx.doi.org/10.1038/s42003-021-01675-4
Descripción
Sumario:Heart failure (HF) occurs frequently among older individuals, and dysfunction of cardiac mitochondria is often observed. We here show the cardiac-specific downregulation of a certain mitochondrial component during the chronological aging of mice, which is detrimental to the heart. MitoNEET is a mitochondrial outer membrane protein, encoded by CDGSH iron sulfur domain 1 (CISD1). Expression of mitoNEET was specifically downregulated in the heart and kidney of chronologically aged mice. Mice with a constitutive cardiac-specific deletion of CISD1 on the C57BL/6J background showed cardiac dysfunction only after 12 months of age and developed HF after 16 months; whereas irregular morphology and higher levels of reactive oxygen species in their cardiac mitochondria were observed at earlier time points. Our results suggest a possible mechanism by which cardiac mitochondria may gradually lose their integrity during natural aging, and shed light on an uncharted molecular basis closely related to age-associated HF.