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Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
Heart failure (HF) occurs frequently among older individuals, and dysfunction of cardiac mitochondria is often observed. We here show the cardiac-specific downregulation of a certain mitochondrial component during the chronological aging of mice, which is detrimental to the heart. MitoNEET is a mito...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846856/ https://www.ncbi.nlm.nih.gov/pubmed/33514783 http://dx.doi.org/10.1038/s42003-021-01675-4 |
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author | Furihata, Takaaki Takada, Shingo Kakutani, Naoya Maekawa, Satoshi Tsuda, Masaya Matsumoto, Junichi Mizushima, Wataru Fukushima, Arata Yokota, Takashi Enzan, Nobuyuki Matsushima, Shouji Handa, Haruka Fumoto, Yoshizuki Nio-Kobayashi, Junko Iwanaga, Toshihiko Tanaka, Shinya Tsutsui, Hiroyuki Sabe, Hisataka Kinugawa, Shintaro |
author_facet | Furihata, Takaaki Takada, Shingo Kakutani, Naoya Maekawa, Satoshi Tsuda, Masaya Matsumoto, Junichi Mizushima, Wataru Fukushima, Arata Yokota, Takashi Enzan, Nobuyuki Matsushima, Shouji Handa, Haruka Fumoto, Yoshizuki Nio-Kobayashi, Junko Iwanaga, Toshihiko Tanaka, Shinya Tsutsui, Hiroyuki Sabe, Hisataka Kinugawa, Shintaro |
author_sort | Furihata, Takaaki |
collection | PubMed |
description | Heart failure (HF) occurs frequently among older individuals, and dysfunction of cardiac mitochondria is often observed. We here show the cardiac-specific downregulation of a certain mitochondrial component during the chronological aging of mice, which is detrimental to the heart. MitoNEET is a mitochondrial outer membrane protein, encoded by CDGSH iron sulfur domain 1 (CISD1). Expression of mitoNEET was specifically downregulated in the heart and kidney of chronologically aged mice. Mice with a constitutive cardiac-specific deletion of CISD1 on the C57BL/6J background showed cardiac dysfunction only after 12 months of age and developed HF after 16 months; whereas irregular morphology and higher levels of reactive oxygen species in their cardiac mitochondria were observed at earlier time points. Our results suggest a possible mechanism by which cardiac mitochondria may gradually lose their integrity during natural aging, and shed light on an uncharted molecular basis closely related to age-associated HF. |
format | Online Article Text |
id | pubmed-7846856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78468562021-02-08 Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure Furihata, Takaaki Takada, Shingo Kakutani, Naoya Maekawa, Satoshi Tsuda, Masaya Matsumoto, Junichi Mizushima, Wataru Fukushima, Arata Yokota, Takashi Enzan, Nobuyuki Matsushima, Shouji Handa, Haruka Fumoto, Yoshizuki Nio-Kobayashi, Junko Iwanaga, Toshihiko Tanaka, Shinya Tsutsui, Hiroyuki Sabe, Hisataka Kinugawa, Shintaro Commun Biol Article Heart failure (HF) occurs frequently among older individuals, and dysfunction of cardiac mitochondria is often observed. We here show the cardiac-specific downregulation of a certain mitochondrial component during the chronological aging of mice, which is detrimental to the heart. MitoNEET is a mitochondrial outer membrane protein, encoded by CDGSH iron sulfur domain 1 (CISD1). Expression of mitoNEET was specifically downregulated in the heart and kidney of chronologically aged mice. Mice with a constitutive cardiac-specific deletion of CISD1 on the C57BL/6J background showed cardiac dysfunction only after 12 months of age and developed HF after 16 months; whereas irregular morphology and higher levels of reactive oxygen species in their cardiac mitochondria were observed at earlier time points. Our results suggest a possible mechanism by which cardiac mitochondria may gradually lose their integrity during natural aging, and shed light on an uncharted molecular basis closely related to age-associated HF. Nature Publishing Group UK 2021-01-29 /pmc/articles/PMC7846856/ /pubmed/33514783 http://dx.doi.org/10.1038/s42003-021-01675-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Furihata, Takaaki Takada, Shingo Kakutani, Naoya Maekawa, Satoshi Tsuda, Masaya Matsumoto, Junichi Mizushima, Wataru Fukushima, Arata Yokota, Takashi Enzan, Nobuyuki Matsushima, Shouji Handa, Haruka Fumoto, Yoshizuki Nio-Kobayashi, Junko Iwanaga, Toshihiko Tanaka, Shinya Tsutsui, Hiroyuki Sabe, Hisataka Kinugawa, Shintaro Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure |
title | Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure |
title_full | Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure |
title_fullStr | Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure |
title_full_unstemmed | Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure |
title_short | Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure |
title_sort | cardiac-specific loss of mitoneet expression is linked with age-related heart failure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846856/ https://www.ncbi.nlm.nih.gov/pubmed/33514783 http://dx.doi.org/10.1038/s42003-021-01675-4 |
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