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MicroRNA-130a Is Elevated in Thyroid Eye Disease and Increases Lipid Accumulation in Fibroblasts Through the Suppression of AMPK

PURPOSE: Thyroid eye disease (TED) is a condition that causes the tissue behind the eye to become inflamed and can result in excessive fatty tissue accumulation in the orbit. Two subpopulations of fibroblasts reside in the orbit: those that highly express Thy1 (Thy1+) and those with little or no Thy...

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Detalles Bibliográficos
Autores principales: Hammond, Christine L., Roztocil, Elisa, Gonzalez, Mithra O., Feldon, Steven E., Woeller, Collynn F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846950/
https://www.ncbi.nlm.nih.gov/pubmed/33507228
http://dx.doi.org/10.1167/iovs.62.1.29