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Pharmacokinetics and dialytic clearance of apixaban during in vitro continuous renal replacement therapy
BACKGROUND: To evaluate the transmembrane clearance (CL(TM)) of apixaban during modeled in vitro continuous renal replacement therapy (CRRT), assess protein binding and circuit adsorption, and provide initial dosing recommendations. METHODS: Apixaban was added to the CRRT circuit and serial pre-filt...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847018/ https://www.ncbi.nlm.nih.gov/pubmed/33516188 http://dx.doi.org/10.1186/s12882-021-02248-7 |