LncRNA APCDD1L-AS1 induces icotinib resistance by inhibition of EGFR autophagic degradation via the miR-1322/miR-1972/miR-324-3p-SIRT5 axis in lung adenocarcinoma

BACKGROUND: Epidermal growth factor receptor-tyrosinase kinase inhibitor (EGFR-TKI) resistance is the major obstacle in the treatment of lung adenocarcinoma (LUAD) patients harboring EGFR-sensitive mutations. However, the long non-coding RNAs (lncRNAs) related to EGFR-TKIs resistance and their funct...

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Detalles Bibliográficos
Autores principales: Wu, Jie, Zheng, Chunlei, Wang, Yizhe, Yang, Zichang, Li, Ce, Fang, Wanxia, Jin, Yue, Hou, Kezuo, Cheng, Yang, Qi, Jianfei, Qu, Xiujuan, Liu, Yunpeng, Che, Xiaofang, Hu, Xuejun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847171/
https://www.ncbi.nlm.nih.gov/pubmed/33516270
http://dx.doi.org/10.1186/s40364-021-00262-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847171/
https://www.ncbi.nlm.nih.gov/pubmed/33516270
http://dx.doi.org/10.1186/s40364-021-00262-3

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