In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics

The microtubule-associated protein tau (tau) forms hyperphosphorylated aggregates in the brains of tauopathy patients that can be pathologically and biochemically defined as distinct tau strains. Recent studies show that these tau strains exhibit strain-specific biological activities, also referred...

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Detalles Bibliográficos
Autores principales: Xu, Hong, O’Reilly, Mia, Gibbons, Garrett S., Changolkar, Lakshmi, McBride, Jennifer D., Riddle, Dawn M., Zhang, Bin, Stieber, Anna, Nirschl, Jeffrey, Kim, Soo-Jung, Hoxha, Kevt-her, Brunden, Kurt R., Schellenberg, Gerard D., Trojanowski, John Q., Lee, Virginia M.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847465/
https://www.ncbi.nlm.nih.gov/pubmed/33385254
http://dx.doi.org/10.1007/s00401-020-02253-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847465/
https://www.ncbi.nlm.nih.gov/pubmed/33385254
http://dx.doi.org/10.1007/s00401-020-02253-4

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