Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition

Background: Colorectal cancer (CRC) and the associated metastatic lesions are reported to be hypoxic. Hypoxia is a common feature in the tumor microenvironment and a potent stimulant of CRC. We have identified a regulatory role of Nur77 on Akt activation to enhance β-catenin signaling essential for...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Zeyu, To, Sally K. Y., Zhang, Shuaishuai, Deng, Shan, Artemenko, Margarita, Zhang, Minda, Tang, Juan, Zeng, Jin-Zhang, Wong, Alice S.T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847671/
https://www.ncbi.nlm.nih.gov/pubmed/33537093
http://dx.doi.org/10.7150/thno.52190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847671/
https://www.ncbi.nlm.nih.gov/pubmed/33537093
http://dx.doi.org/10.7150/thno.52190

Ejemplares similares