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Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition
Background: Colorectal cancer (CRC) and the associated metastatic lesions are reported to be hypoxic. Hypoxia is a common feature in the tumor microenvironment and a potent stimulant of CRC. We have identified a regulatory role of Nur77 on Akt activation to enhance β-catenin signaling essential for...
Autores principales: | Shi, Zeyu, To, Sally K. Y., Zhang, Shuaishuai, Deng, Shan, Artemenko, Margarita, Zhang, Minda, Tang, Juan, Zeng, Jin-Zhang, Wong, Alice S.T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847671/ https://www.ncbi.nlm.nih.gov/pubmed/33537093 http://dx.doi.org/10.7150/thno.52190 |
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