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Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition

Background: Colorectal cancer (CRC) and the associated metastatic lesions are reported to be hypoxic. Hypoxia is a common feature in the tumor microenvironment and a potent stimulant of CRC. We have identified a regulatory role of Nur77 on Akt activation to enhance β-catenin signaling essential for...

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Detalles Bibliográficos
Autores principales:	Shi, Zeyu, To, Sally K. Y., Zhang, Shuaishuai, Deng, Shan, Artemenko, Margarita, Zhang, Minda, Tang, Juan, Zeng, Jin-Zhang, Wong, Alice S.T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847671/ https://www.ncbi.nlm.nih.gov/pubmed/33537093 http://dx.doi.org/10.7150/thno.52190

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