Cargando…

Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability

OBJECTIVE: This study was intended to utilize lecithin-based mixed polymeric micelles (lbMPMs) for enhancing the solubility and bioavailability of honokiol and magnolol to resolve the hindrance of their extreme hydrophobicity on the clinical applications. METHODS: Lecithin was selected to increase t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Hong-Liang, Cheng, Wen-Ting, Chen, Ling-Chun, Ho, Hsiu-O, Lin, Shyr-Yi, Hsieh, Chien-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847769/ https://www.ncbi.nlm.nih.gov/pubmed/33536753 http://dx.doi.org/10.2147/IJN.S290444

Ejemplares similares

Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin
por: Chen, Ling-Chun, et al.
Publicado: (2016)

Corrigendum: Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin
por: Chen, Ling-Chun, et al.
Publicado: (2017)

Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
por: Lin, Yi-Ruu, et al.
Publicado: (2009)

Honokiol and Magnolol: Insights into Their Antidermatophytic Effects
por: Trifan, Adriana, et al.
Publicado: (2021)

Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration
por: Yu, Chung-Ping, et al.
Publicado: (2021)

Inhibitory effects of magnolol and honokiol on human calcitonin aggregation
por: Guo, Caiao, et al.
Publicado: (2015)

Honokiol and Magnolol as Multifunctional Antioxidative Molecules for Dermatologic Disorders
por: Shen, Jui-Lung, et al.
Publicado: (2010)

Synthesis of magnolol and honokiol derivatives and their effect against hepatocarcinoma cells
por: Maioli, Margherita, et al.
Publicado: (2018)

Lecithin-Stabilized Polymeric Micelles (L(sb)PMs) for Delivering Quercetin: Pharmacokinetic Studies and Therapeutic Effects of Quercetin Alone and in Combination with Doxorubicin
por: Chang, Chia-En, et al.
Publicado: (2018)

Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus(®)-Poloxamer 188
por: Li, Guoyuan, et al.
Publicado: (2020)

Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
por: Lin, Yiping, et al.
Publicado: (2021)

Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus
por: Kim, Su Young, et al.
Publicado: (2015)

Disruption of Bacterial Thiol-Dependent Redox Homeostasis by Magnolol and Honokiol as an Antibacterial Strategy
por: Ouyang, Yanfang, et al.
Publicado: (2023)

Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles
por: Chen, Ying-Chen, et al.
Publicado: (2015)

Effects of Magnolol and Honokiol on Adhesion, Yeast-Hyphal Transition, and Formation of Biofilm by Candida albicans
por: Sun, Lingmei, et al.
Publicado: (2015)

Pharmaceutical Evaluation of Honokiol and Magnolol on Apoptosis and Migration Inhibition in Human Bladder Cancer Cells
por: Wang, Hisao-Hsien, et al.
Publicado: (2020)

Polymeric Micelles, a Promising Drug Delivery System to Enhance Bioavailability of Poorly Water-Soluble Drugs
por: Xu, Wei, et al.
Publicado: (2013)

Development and characterization of self-assembling lecithin-based mixed polymeric micelles containing quercetin in cancer treatment and an in vivo pharmacokinetic study
por: Chen, Ling-Chun, et al.
Publicado: (2016)

Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties
por: Usach, Iris, et al.
Publicado: (2021)

Physical and Pharmacokinetic Characterizations of trans-Resveratrol (t-Rev) Encapsulated with Self-Assembling Lecithin-based Mixed Polymeric Micelles (saLMPMs)
por: Li, Tzu-Pin, et al.
Publicado: (2017)

Highly Water-Soluble Solid Dispersions of Honokiol: Preparation, Solubility, and Bioavailability Studies and Anti-Tumor Activity Evaluation
por: Wang, Li, et al.
Publicado: (2019)

Biodegradable polymeric micelles coencapsulating paclitaxel and honokiol: a strategy for breast cancer therapy in vitro and in vivo
por: Wang, Ning, et al.
Publicado: (2017)

Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABA(A) receptor ligands
por: Rycek, Lukas, et al.
Publicado: (2015)

Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas
por: Cheng, Yu-Chen, et al.
Publicado: (2016)

Antifungal Effect of Magnolol and Honokiol from Magnolia officinalis on Alternaria alternata Causing Tobacco Brown Spot
por: Chen, Ya-Han, et al.
Publicado: (2019)

Synthesis, Characterization and Biological Evaluation of Magnolol and Honokiol Derivatives with 1,3,5-Triazine of Metformin Cyclization
por: Ren, Cui, et al.
Publicado: (2020)

Enhancing oral bioavailability of quercetin using novel soluplus polymeric micelles
por: Dian, Linghui, et al.
Publicado: (2014)

Honokiol, magnolol and its monoacetyl derivative show strong anti-fungal effect on Fusarium isolates of clinical relevance
por: Oufensou, Safa, et al.
Publicado: (2019)

In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA)
por: Zuo, Guo-Ying, et al.
Publicado: (2015)

Potential Application of the WST-8-mPMS Assay for Rapid Viable Microorganism Detection
por: Chen, Cheng-Han, et al.
Publicado: (2023)

Supplemental magnolol or honokiol attenuates adverse effects in broilers infected with Salmonella pullorum by modulating mucosal gene expression and the gut microbiota
por: Chen, Fang, et al.
Publicado: (2021)

Oxidation and Reduction Dual-Responsive Polymeric Prodrug Micelles Co-delivery Precisely Prescribed Paclitaxel and Honokiol for Laryngeal Carcinoma Combination Therapy
por: Zhou, Lanzhu, et al.
Publicado: (2022)

Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo
por: Kim, Sang-Bum, et al.
Publicado: (2018)

Magnolol and Honokiol Attenuate Apoptosis of Enterotoxigenic Escherichia Coli-Induced Intestinal Epithelium by Maintaining Secretion and Absorption Homeostasis and Protecting Mucosal Integrity
por: Deng, Yanli, et al.
Publicado: (2018)

Cheminformatics-driven discovery of polymeric micelle formulations for poorly soluble drugs
por: Alves, Vinicius M., et al.
Publicado: (2019)

Self-Assembling Lecithin-Based Mixed Polymeric Micelles for Nose to Brain Delivery of Clozapine: In-vivo Assessment of Drug Efficacy via Radiobiological Evaluation
por: M Elsharkawy, Fatma, et al.
Publicado: (2023)

l-Carnitine conjugated chitosan-stearic acid polymeric micelles for improving the oral bioavailability of paclitaxel
por: Yang, Tan, et al.
Publicado: (2020)

Honokiol Dimers and Magnolol Derivatives with New Carbon Skeletons from the Roots of Magnolia officinalis and Their Inhibitory Effects on Superoxide Anion Generation and Elastase Release
por: Shih, Hung-Cheng, et al.
Publicado: (2013)

Enhanced oral bioavailability of docetaxel by lecithin nanoparticles: preparation, in vitro, and in vivo evaluation
por: Hu, Kaili, et al.
Publicado: (2012)

Enhanced Oral Bioavailability of the Pharmacologically Active Lignin Magnolol via Zr-Based Metal Organic Framework Impregnation
por: Santos, Joshua H., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_48ecfe6d3uajjoa7jpe44f99ul