Mechanical Stretch Induces Smooth Muscle Cell Dysfunction by Regulating ACE2 via P38/ATF3 and Post-transcriptional Regulation by miR-421

Mechanical stretch promotes deregulation of vascular smooth muscle cell (VSMC) functions during hypertension-induced vascular remodeling. ACE2 has a wide range of cardiovascular and renal protective effects. Loss of ACE2 is associated with cardiovascular disease, but little is known about the regula...

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Detalles Bibliográficos
Autores principales: Liu, Xiaolin, Liu, Xinxin, Li, Mengmeng, Zhang, Yu, Chen, Weijia, Zhang, Meng, Zhang, Cheng, Zhang, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848200/
https://www.ncbi.nlm.nih.gov/pubmed/33536929
http://dx.doi.org/10.3389/fphys.2020.540591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848200/
https://www.ncbi.nlm.nih.gov/pubmed/33536929
http://dx.doi.org/10.3389/fphys.2020.540591

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