Cargando…

PAR2 Inhibition Enhanced the Sensitivity of Colorectal Cancer Cells to 5-FU and Reduced EMT Signaling

The aim of this study was to investigate the underlying mechanisms that transforming growth factor-β (TGF-β)-mediated epithelial-to-mesenchymal transition (EMT) in tumor cells contributes to 5-FU resistance. A series of experiments involving cell viability and caspase activity analyses, siRNA transf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Quan, Qiuying, Zhong, Fengyun, Wang, Xinwei, Chen, Kai, Guo, Lingchuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cognizant Communication Corporation 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848255/ https://www.ncbi.nlm.nih.gov/pubmed/30841957 http://dx.doi.org/10.3727/096504018X15442985680348

Ejemplares similares

HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins
por: Sun, Lei, et al.
Publicado: (2017)

DCBLD2 Affects the Development of Colorectal Cancer via EMT and Angiogenesis and Modulates 5-FU Drug Resistance
por: Xie, Pan, et al.
Publicado: (2021)

Inhibition of CDK1 Reverses the Resistance of 5-Fu in Colorectal Cancer
por: Zhu, Yiping, et al.
Publicado: (2020)

CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer
por: Yang, Kai, et al.
Publicado: (2016)

Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-κB activation
por: Fu, Jinbo, et al.
Publicado: (2019)

Inhibition of Mus81 by siRNA enhances sensitivity to 5-FU in breast carcinoma cell lines
por: Qian, Ying, et al.
Publicado: (2014)

Inhibition of protein FAK enhances 5-FU chemosensitivity to gastric carcinoma via p53 signaling pathways
por: Hou, Jingjing, et al.
Publicado: (2019)

GALNT6 Knockdown Inhibits the Proliferation and Migration of Colorectal Cancer Cells and Increases the Sensitivity of Cancer Cells to 5-FU
por: Peng, Xiangdong, et al.
Publicado: (2021)

Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells
por: Gonçalves-Ribeiro, Samuel, et al.
Publicado: (2016)

KLK8 promotes the proliferation and metastasis of colorectal cancer via the activation of EMT associated with PAR1
por: Hua, Qing, et al.
Publicado: (2021)

GDC-0326 Enhances the Effects of 5-Fu in Colorectal Cancer Cells by Inducing Necroptotic Death
por: Zhang, Zizhen, et al.
Publicado: (2021)

5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice
por: Wang, Yongsheng, et al.
Publicado: (2010)

Combinational inhibition of EGFR and YAP reverses 5-Fu resistance in colorectal cancer
por: Huang, Changhao, et al.
Publicado: (2020)

HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy
por: Nagaraju, Ganji Purnachandra, et al.
Publicado: (2014)

Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug-resistant human hepatocellular carcinoma cells to 5-FU
por: TANG, BO, et al.
Publicado: (2016)

Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug-resistant human hepatocellular carcinoma cells to 5-FU
por: Tang, Bo, et al.
Publicado: (2018)

RETRACTED ARTICLE: Inhibition of EZH2 enhances the therapeutic effect of 5-FU via PUMA upregulation in colorectal cancer
por: Tan, Xiao, et al.
Publicado: (2020)

Retraction Note: Inhibition of EZH2 enhances the therapeutic effect of 5-FU via PUMA upregulation in colorectal cancer
por: Tan, Xiao, et al.
Publicado: (2023)

[Retracted] Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug‑resistant human hepatocellular carcinoma cells to 5‑FU
por: Tang, Bo, et al.
Publicado: (2023)

Managing 5FU Cardiotoxicity in Colorectal Cancer Treatment
por: Anaka, Matthew, et al.
Publicado: (2022)

Jiedu Sangen Decoction Inhibits the Invasion and Metastasis of Colorectal Cancer Cells by Regulating EMT through the Hippo Signaling Pathway
por: Yuan, Li, et al.
Publicado: (2019)

Fu-Fang-Jin-Qian-Cao herbal granules protect against the calcium oxalate-induced renal EMT by inhibiting the TGF-β/smad pathway
por: Liu, Wen-Rui, et al.
Publicado: (2020)

Metformin Inhibited Proliferation and Metastasis of Colorectal Cancer and presented a Synergistic Effect on 5-FU
por: Sang, Jing, et al.
Publicado: (2020)

Up-regulation of FAT4 enhances the chemosensitivity of colorectal cancer cells treated by 5-FU
por: Li, Qianyuan, et al.
Publicado: (2020)

Halofuginone inhibits tumorigenic progression of 5-FU-resistant human colorectal cancer HCT-15/FU cells by targeting miR-132-3p in vitro
por: Wang, Chen, et al.
Publicado: (2020)

miR-106a Reduces 5-Fluorouracil (5-FU) Sensitivity of Colorectal Cancer by Targeting Dual-Specificity Phosphatases 2 (DUSP2)
por: Qin, Yan, et al.
Publicado: (2018)

Curcumol increases the sensitivity of colon cancer to 5-FU by regulating Wnt/β-catenin signaling
por: Gao, Jinfeng, et al.
Publicado: (2021)

The role of GLI1 for 5-Fu resistance in colorectal cancer
por: Zhang, Lining, et al.
Publicado: (2017)

Association of 5-FU Therapeutic Drug Monitoring to DPD Phenotype Assessment May Reduce 5-FU Under-Exposure
por: Dolat, Marine, et al.
Publicado: (2020)

Deletion of NEMO Inhibits EMT and Reduces Metastasis in KPC Mice
por: Tsesmelis, Miltiadis, et al.
Publicado: (2021)

Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth
por: Yan, Zhengwei, et al.
Publicado: (2021)

TIMP-2 regulates 5-Fu resistance via the ERK/MAPK signaling pathway in colorectal cancer
por: Zhang, Guolin, et al.
Publicado: (2022)

Knockdown of MMP-1 inhibits the progression of colorectal cancer by suppressing the PI3K/Akt/c-myc signaling pathway and EMT
por: Wang, Kai, et al.
Publicado: (2020)

IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced
por: Zhu, Huixia, et al.
Publicado: (2017)

Disulfiram Enhances the Antineoplastic Activity and Sensitivity of Murine Hepatocellular Carcinoma to 5-FU via Redox Management
por: Hassan, Iftekhar, et al.
Publicado: (2023)

Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways
por: Zhu, Xiaoqin, et al.
Publicado: (2021)

miR-329 regulates the sensitivity of 5-FU in chemotherapy of colorectal cancer by targeting E2F1
por: Yin, Jie, et al.
Publicado: (2018)

Silencing of NRF2 Reduces the Expression of ALDH1A1 and ALDH3A1 and Sensitizes to 5-FU in Pancreatic Cancer Cells
por: Duong, Hong-Quan, et al.
Publicado: (2017)

Doxycycline inhibits breast cancer EMT and metastasis through PAR-1/NF-κB/miR-17/E-cadherin pathway
por: Zhong, Weilong, et al.
Publicado: (2017)

Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs
por: Ahmad, Aamir, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_uarvmmargtvmgm28ja8nn7ep2u