Mitomycin‐C treatment during differentiation of induced pluripotent stem cell‐derived dopamine neurons reduces proliferation without compromising survival or function in vivo

Nongenetic methodologies to reduce undesirable proliferation would be valuable when generating dopamine neurons from stem cells for transplantation in Parkinson's disease (PD). To this end, we modified an established method for controlled differentiation of human induced pluripotent stem cells...

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Detalles Bibliográficos
Autores principales: Hiller, Benjamin M., Marmion, David J., Gross, Rachel M., Thompson, Cayla A., Chavez, Carrie A., Brundin, Patrik, Wakeman, Dustin R., McMahon, Christopher W., Kordower, Jeffrey H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Pluripotent Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848297/
https://www.ncbi.nlm.nih.gov/pubmed/32997443
http://dx.doi.org/10.1002/sctm.20-0014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848297/
https://www.ncbi.nlm.nih.gov/pubmed/32997443
http://dx.doi.org/10.1002/sctm.20-0014

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