Reactive Oxygen Species-Mediated Cezanne Inactivation by Oxidation of its Catalytic Cysteine Residue in Hepatocellular Carcinoma

Cysteine oxidation occurs at the active site of deubiquitinases (DUBs) during many biologic signaling cascades. Here we report that hepatocellular carcinoma cells (HCCs) generated higher levels of endogenous reactive oxygen species (ROS). This elevated ROS production was inhibited by NADPH oxidase i...

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Detalles Bibliográficos
Autores principales: Yin, Zhongyuan, Yang, Lin, Wu, Feng, Fan, Jinshuo, Xu, Juanjuan, Jin, Yang, Yang, Guanghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cognizant Communication Corporation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848393/
https://www.ncbi.nlm.nih.gov/pubmed/31072419
http://dx.doi.org/10.3727/096504019X15566157027506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848393/
https://www.ncbi.nlm.nih.gov/pubmed/31072419
http://dx.doi.org/10.3727/096504019X15566157027506

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