Cargando…

Immunogenicity Challenges Associated with Subcutaneous Delivery of Therapeutic Proteins

The subcutaneous route of administration has provided convenient and non-inferior delivery of therapeutic proteins compared to intravenous infusion, but there is potential for enhanced immunogenicity toward subcutaneously administered proteins in a subset of patients. Unwanted anti-drug antibody res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jarvi, Nicole L., Balu-Iyer, Sathy V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848667/ https://www.ncbi.nlm.nih.gov/pubmed/33523413 http://dx.doi.org/10.1007/s40259-020-00465-4

Ejemplares similares

Understanding preclinical and clinical immunogenicity risks in novel biotherapeutics development
por: Sauna, Zuben E., et al.
Publicado: (2023)

Rational design of a nanoparticle platform for oral prophylactic immunotherapy to prevent immunogenicity of therapeutic proteins
por: Nguyen, Nhan H., et al.
Publicado: (2021)

Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics
por: Curreri, Alexander M., et al.
Publicado: (2023)

Immunogenicity of therapeutic proteins: Influence of aggregation
por: Ratanji, Kirsty D., et al.
Publicado: (2014)

Immunogenicity of Therapeutic Proteins: The Use of Animal Models
por: Brinks, Vera, et al.
Publicado: (2011)

Characterization of immunogenicity of avian influenza antigens encapsulated in PLGA nanoparticles following mucosal and subcutaneous delivery in chickens
por: Alkie, Tamiru Negash, et al.
Publicado: (2018)

Delivery of oligonucleotide‐based therapeutics: challenges and opportunities
por: Hammond, Suzan M, et al.
Publicado: (2021)

Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives
por: Esposito, Carla Lucia, et al.
Publicado: (2018)

Delivery Approaches for Therapeutic Genome Editing and Challenges
por: Ates, Ilayda, et al.
Publicado: (2020)

Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins
por: Smith, Alison, et al.
Publicado: (2016)

Protein-protein conjugate nanoparticles for malaria antigen delivery and enhanced immunogenicity
por: Scaria, Puthupparampil V., et al.
Publicado: (2017)

Humanized Mouse Model of Ovarian Cancer Recapitulates Patient Solid Tumor Progression, Ascites Formation, and Metastasis
por: Bankert, Richard B., et al.
Publicado: (2011)

Editorial: Immunogenicity of Proteins Used as Therapeutics
por: Sauna, Zuben E., et al.
Publicado: (2020)

Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges
por: Zhou, Jiehua, et al.
Publicado: (2013)

Current Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAs
por: Johannes, Ludger, et al.
Publicado: (2018)

Natamycin Ocular Delivery: Challenges and Advancements in Ocular Therapeutics
por: Mascarenhas, Mabel, et al.
Publicado: (2023)

Subcutaneous delivery of sumatriptan in the treatment of migraine and primary headache
por: Moore, Johanna C, et al.
Publicado: (2012)

Progress and challenges towards targeted delivery of cancer therapeutics
por: Rosenblum, Daniel, et al.
Publicado: (2018)

Promises and Challenges of Immunogenic Chemotherapy in Multiple Myeloma
por: Johnstone, Megan, et al.
Publicado: (2022)

Peptide size profile and residual immunogenic milk protein or peptide content in extensively hydrolyzed infant formulas
por: Nutten, Sophie, et al.
Publicado: (2019)

In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges
por: Behr, Matthew, et al.
Publicado: (2021)

An Overview of the Stability and Delivery Challenges of Commercial Nucleic Acid Therapeutics
por: Ingle, Rahul G., et al.
Publicado: (2023)

Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review
por: Wang, Yang, et al.
Publicado: (2023)

Advances in Subcutaneous Delivery Systems of Biomacromolecular Agents for Diabetes Treatment
por: Li, Chen, et al.
Publicado: (2021)

Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics
por: Davda, Jasmine, et al.
Publicado: (2019)

Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
por: Ferreira, Raquel, et al.
Publicado: (2020)

Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities
por: Bittner, Beate, et al.
Publicado: (2018)

Pharmacokinetics and Immunogenicity of Frunevetmab in Osteoarthritic Cats Following Intravenous and Subcutaneous Administration
por: Walters, Rodney R., et al.
Publicado: (2021)

Development of New Formulations of Biologics: Expectations, Immunogenicity, and Safety for Subcutaneous Trastuzumab
por: Pimentel, Franklin Fernandes, et al.
Publicado: (2018)

Lanreotide depot deep subcutaneous injection: a new method of delivery and its associated benefits
por: Carmichael, John D
Publicado: (2012)

Immunogenicity Risk Assessment for Multi-specific Therapeutics
por: Kroenke, Mark A., et al.
Publicado: (2021)

A Psittacine bite and subcutaneous basidiobolomycosis: A case with a therapeutic challenge
por: Choubey, Shivani, et al.
Publicado: (2023)

Immunotherapy with subcutaneous immunogenic autologous tumor lysate increases murine glioblastoma survival
por: Belmans, Jochen, et al.
Publicado: (2017)

Nitric Oxide Nano-Delivery Systems for Cancer Therapeutics: Advances and Challenges
por: Vong, Long Binh, et al.
Publicado: (2020)

Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges
por: Oshchepkova, Anastasiya, et al.
Publicado: (2023)

Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements
por: Badkar, Advait V, et al.
Publicado: (2021)

Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery
por: Yang, Yoosoo, et al.
Publicado: (2018)

Ocular Delivery of Therapeutic Proteins: A Review
por: Shastri, Divyesh H., et al.
Publicado: (2023)

Aggregation of protein therapeutics enhances their immunogenicity: causes and mitigation strategies
por: Lundahl, Mimmi L. E., et al.
Publicado: (2021)

Immunogenicity of Protein Therapeutics: A Lymph Node Perspective
por: Fu, Kristy, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_f6cthltgshapp2aau3999cobn5