AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model

Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the mouse retina results in a CRB dose-dependent retinal phenotype. In this study, we present a novel Müller cell-specific Crb1(KO)Crb2(LowMGC) retinitis pigmentosa mouse model (complete loss of CRB1 and reduced le...

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Detalles Bibliográficos
Autores principales: Buck, Thilo M., Vos, Rogier M., Alves, C. Henrique, Wijnholds, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848734/
https://www.ncbi.nlm.nih.gov/pubmed/33575434
http://dx.doi.org/10.1016/j.omtm.2020.12.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848734/
https://www.ncbi.nlm.nih.gov/pubmed/33575434
http://dx.doi.org/10.1016/j.omtm.2020.12.012

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