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Oligomer β-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice
The activity of Ras, a small GTPase protein, is increased in brains with Alzheimer’s disease. The objective of this study was to determine the influence of oligomeric Aβ(1-42) on the activation of Ras, and the involvement of the Ras hyperactivity in Aβ(1-42)-induced deficits in spatial cognition and...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848859/ https://www.ncbi.nlm.nih.gov/pubmed/33536910 http://dx.doi.org/10.3389/fphar.2020.595360 |