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Oligomer β-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice

The activity of Ras, a small GTPase protein, is increased in brains with Alzheimer’s disease. The objective of this study was to determine the influence of oligomeric Aβ(1-42) on the activation of Ras, and the involvement of the Ras hyperactivity in Aβ(1-42)-induced deficits in spatial cognition and...

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Detalles Bibliográficos
Autores principales:	Wang, Ya, Shi, Zhaochun, Zhang, Yajie, Yan, Jun, Yu, Wenfeng, Chen, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848859/ https://www.ncbi.nlm.nih.gov/pubmed/33536910 http://dx.doi.org/10.3389/fphar.2020.595360

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