20‐HETE synthesis inhibition attenuates traumatic brain injury–induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC‐1α pathway: A translational study

OBJECTIVES: 20‐hydroxyeicosatetraenoic acid (20‐HETE) is a metabolite of arachidonic acid catalysed by cytochrome P450 enzymes and plays an important role in cell death and proliferation. We hypothesized that 20‐HETE synthesis inhibition may have protective effects in traumatic brain injury (TBI) an...

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Detalles Bibliográficos
Autores principales: Cui, Wenxing, Wu, Xun, Shi, Yingwu, Guo, Wei, Luo, Jianing, Liu, Haixiao, Zheng, Longlong, Du, Yong, Wang, Ping, Wang, Qiang, Feng, Dayun, Ge, Shunnan, Qu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848954/
https://www.ncbi.nlm.nih.gov/pubmed/33314534
http://dx.doi.org/10.1111/cpr.12964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7848954/
https://www.ncbi.nlm.nih.gov/pubmed/33314534
http://dx.doi.org/10.1111/cpr.12964

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